A clinical study comparing manic and mixed episodes in patients with bipolar disorder.

نویسندگان

  • Angela Maria Schwartzmann
  • José Antonio Amaral
  • Cilly Issler
  • Sheila C Caetano
  • Renata S Tamada
  • Karla Mathias de Almeida
  • Marcia Brito de Macedo Soares
  • Rodrigo da Silva Dias
  • Cristiana C Rocca
  • Beny Lafer
چکیده

OBJECTIVE Mixed episodes have been described as more severe than manic episodes, especially due to their longer duration and their association with higher rates of suicide attempts, hospitalization and psychotic symptoms. The purpose of this study was to compare the severity between mixed and pure manic episodes according to DSM-IV criteria, through the evaluation of sociodemographic data and clinical characteristics. METHOD Twenty-nine bipolar I patients presenting acute mixed episodes were compared to 20 bipolar I patients with acute manic episodes according to DSM-IV criteria. We analyzed (cross-sectionally) episode length, presence of psychotic symptoms, frequency of suicide attempts and hospitalization, Young Mania Rating Scale scores, Hamilton Depression Rating Scale scores and the Clinical Global Assessment Scale scores. RESULTS Young Mania Rating Scale scores were higher in manic episodes than in mixed episodes. There were no differences in gender frequency, CGI scores and rates of hospitalization, suicide attempts and psychotic symptoms, when mixed and manic episodes where compared. Patients with mixed episodes were younger. CONCLUSION In our sample, mixed states occurred at an earlier age than manic episodes. Contrary to previous reports, we did not find significant differences between manic and mixed episodes regarding severity of symptomatology, except for manic symptoms ratings, which were higher in acute manic patients. In part, this may be explained by the different criteria adopted on previous studies.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

The Evaluation of Anxiety, Depression and Global Assessment of Functioning in Bipolar Patients at Manic and Mixed Episodes

Background and Aims: This research is carried out with the aim of comparing anxiety, depression and global assessment of functioning between two groups of bipolar patients at mixed and manic episodes. Methods: Using an analytical cross-sectional approach, a sample of 94 patients with mean age of 32 years old (Standard Deviation: 11.3), who had been categorically diagnosed with bipolar disorder ...

متن کامل

Comparison of the effect of lithium plus quetiapine with lithium plus risperidone in children and adolescents with bipolar I disorder: a randomized clinical trial

Background: In the treatment of bipolar disorder in youths, often more than one medication should be prescribed. In the current study, we compared the efficacy and tolerability of the combination of lithium and quetiapine with lithium and risperidone in the treatment of manic or mixed episodes in children and adolescents. Methods: Thirty patients (aged 10-18 years) who were hospitalized for ...

متن کامل

Clinical Manifestations of Mania in Patients With Bipolar I Disorder Based on the Primary Symptoms in DSM-5

Objective: According to DSM-5, bipolar disorder is a condition in which the patient experiences one or several manic episodes and sometimes major depressive episodes too. The signs and symptoms of the disorders in DSM are generally influenced by cultural and ethnic factors. Therefore, the present study was aimed at identifying the clinical manifestations of mania in bipolar I disorder in Irania...

متن کامل

Effect of dialectical behavior therapy on emotion regulation and mindfulness in patients with bipolar disorder

Background: Bipolar disorder is a debilitating mental disorder characterized by recurrent depression, manic, and hypomanic episodes. In recent studies, effect of dialectical behavior therapy on emotion regulation and mindfulness in bipolar disorder has been less addressed. This study aimed to determine the effect of dialectical behavior therapy on emotion regulation and mindfulness in bipolar d...

متن کامل

Genes Encoding GABA-β and HT1D Receptors in Bipolar I (Manic Phase) Patients

Introduction: According to the cumulative evidence, genes encoding GABA receptors inhibit neurotransmitters in CNS and are intricately involved in the pathogenesis of mood disorders. Based on this hypothesis, these genes may be expressed in bipolar patients. As a result, we evaluated the gene expressions of GABA-β3 and HT1D receptors to assess their associations with bipolar mood disorder....

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Revista brasileira de psiquiatria

دوره 29 2  شماره 

صفحات  -

تاریخ انتشار 2007